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#structuralbiology

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Public
Dave nλ=2dsinθ

New Presidential executive order on proteins:

All amino acids now to be right w̶i̶n̶g̶ handed.

Leftist amino acids to be outlawed.

(Also, Z-DNA is deemed to be Communist, and is prohibited.)

Trans- and cis- peptide bonds to be banned.

Non-binary amino acid Glycine to be banned.

Proline is not a real amino acid and will be banned immediately.

Phenylalanine looks and sounds a bit like Fentanyl, banned immediately.

@strucbio #StructuralBiology #PDB

Public
michael

26-Mar-2025
Remember #ebola?
Zooming in on the #structure of the still lethal #virus

eurekalert.org/news-releases/1 #science #structuralBiology #protein #capsid

EurekAlert!Remember ebola?Kyoto, Japan -- Six years before the start of the COVID-19 pandemic, an Ebola outbreak in West Africa had people fearing the possibility of a global outbreak. This was the first time many had ever heard of the virus, but since it was first identified in 1976, there have actually been more than 20 serious Ebola incidents. Thankfully, none of them had the global reach of the coronavirus. Ebola has not been eradicated, however. This deadly virus, which causes severe hemorrhagic fever in humans and has a fatality rate of about 50%, is still at large and could thus still cause a major outbreak, unless further research finds an effective solution. A major challenge lies in the virus' structure and regulatory mechanisms, which have remained largely unclear. In particular, scientists have long struggled to fully understand its nucleocapsid, the protein shell that plays an important role in genome replication and transcription.
Public
Miguel Correa

Our new preprint on the impact of protein phosphorylation on structures is now out!

Protein phosphorylation is a key regulator of cellular processes.It's ubiquitous, yet the function and relevance of most phosphosites is unknown. Understanding phosphosite function requires elucidating the structural mechanisms through which it acts. (1)

biorxiv.org/content/10.1101/20

@bioinformatics @strucbio #bioinformatics #protein #StructuralBiology

bioRxiv · Global comparative structural analysis of responses to protein phosphorylationPost-translational modifications (PTMs), particularly protein phosphorylation, are key regulators of cellular processes, impacting numerous aspects of protein activity. Despite widespread phosphorylation of eukaryotic proteomes, the function of most phosphosites remains unknown. Elucidating the structural mechanisms underlying phosphorylation is crucial for understanding its regulatory roles. Here, we conducted a comparative structural analysis of phosphorylated and non-phosphorylated proteins taken from the Protein Data Bank (PDB). Our study systematically evaluates how phosphorylation affects backbone conformation, protein dynamics, and mechanical strain. We found that phosphorylation commonly induces small, stabilizing conformational changes through conformational selection and frequently modulates local residue fluctuations, influencing overall protein motion. Notably, a small but significant subset of phosphosites shows mechanical coupling with functional sites, aligning with the domino model of allosteric signal transduction. This work provides a foundation for studying phosphorylation and other PTMs in their structural context, which will guide the rational design of synthetic phosphosites and enable the engineering of PTM-driven regulatory circuits in synthetic biology. ### Competing Interest Statement The authors have declared no competing interest.
Public
Vicomte Folmer af Helvede

#Introduction #Introduktion

I've spent a lot of my life doing #StructuralBiology and playing #Music #ClassicalMusic.

I like to #read #books, mostly #fantasy but also #clifi and #scifi.
A fan of both #StarTrek and #StarWars, each has its merits. (Yes TNG is the best, but only because I grew up with it).

Currently I'm interested in #biosustainability #sustainability, #enzymology and #ProteinEngineering. I think those technologies are important for our future together.

Danish 🇩🇰

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Rita Giordano

Visualization is the topic of the Crystallographic Computing School this year, #IUCr23. cryst.chem.uu.nl/lutz/IUCrScho. I will discuss visualization in statistics. Thank you so much for inviting me, Martin Lutz and Santosh Panjikar. #dataviz #crystallography #structuralbiology. Do you use data visualization? Are you curious to see how to improve the visualization of your crystallographic data? Do you know how your audience perceives your charts? These are some questions I will discuss during my talk.

www.cryst.chem.uu.nlIUCr Crystallographic Computing School 2023
Public
cryo2go :unverified:

#introduction

I've worn many hats: from Luthier to Chimney sweep.

Several years post-PhD (#StructuralBiology and #MolecularBioPhysics) I moved to "self-host" my career as a consultant for #HPC and #CryoEM

As part of the #TwitterMigration I've just launched my 2nd server after testing the waters with @cryoem.social.

The last month or so on #Mastodon has been great. Looking forward to connecting on everything #science #computing and #OpenAccess

@strucbio

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Itamar Kass

I finally have the time to write an #introduction:
I am a #structuralbiology #scientist, currently working in the #biomed industry. I have a long-standing interest in the study the correlation between the 3D structure and dynamics of proteins and their regulation mechanisms. thought my research I had used #NMR, #xrayscattaring, #SPR, FTIR, #moleculardynamics, #modelling, #Docking, #proteindesign and more.
When I have time, I enjoy to #run, specifically do #trailrun with my kids.

Public
Folmer

#Introduction #Introduktion

I've spent a lot of my life doing #StructuralBiology and playing #Music #ClassicalMusic.

I like to #read #books, mostly #fantasy but also #clifi and #scifi.
A fan of both #StarTrek and #StarWars, each has its merits. (Yes TNG is the best, but only because I grew up with it).

Currently I'm interested in #biosustainability #sustainability and work at #DTUBiosustain with #enzymology and #ProteinEngineering to try and make the world a better place.

Danish 😀

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