https://academic.oup.com/pnasnexus/article/4/4/pgae560/8111338?login=false Prediction of hallucinogen persisting perception disorder and thought disturbance symptoms following psychedelic use (Zhou, et al, 2025) #psychedelics #psychedelicresearch #psychedelic

#Colorado Governor Could Grant Mass Pardons For #Psychedelics Related Convictions Under Newly Filed Bill https://www.marijuanamoment.net/colorado-governor-could-grant-mass-pardons-for-psychedelics-related-convictions-under-newly-filed-bill/

https://pubmed.ncbi.nlm.nih.gov/40253356/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Jks6COFDAP2wn10NWIf-H0HaQXEJkWUqtjQ12xwhgtqZed1QU&fc=20250204204106&ff=20250420004047&v=2.18.0.post9+e462414 Mesoscale brain-wide fluctuation analysis: revealing ketamine's rapid antidepressant across multiple brain regions (Cao, et al, 2025) #ketamine #mentalhealth #neuroscience #ketaminetherapy #brains #depression #psychedelic #psychedelics #psychedelictherapy

Shelby Hartman

- https://doubleblindmag.com/author/shelby-hartman/

Happy Bicycle Day to all who celebrate! On this date in 1943, Albert Hofman took the LSD off the shelf that synthesized five years previously, ingested 0.25 milligrams and then rode his bicycle on the first LSD trip. #psychedelics

https://en.wikipedia.org/wiki/History_of_lysergic_acid_diethylamide#%22Bicycle_Day%22

Today in Labor History Today in Labor History April 19, 1943: Albert Hoffman, inventor of LSD, tested his first dose and went for a bike ride. This day is now celebrated as Bicycle Day. “... Little by little I could begin to enjoy the unprecedented colors and plays of shapes that persisted behind my closed eyes. Kaleidoscopic, fantastic images surged in on me, alternating, variegated, opening and then closing themselves in circles and spirals, exploding in colored fountains, rearranging and hybridizing themselves in constant flux ...” And from that date forward, working class people could finally afford to go on a trip. Hoffman later went on to isolate psilicyben, the active hallucinogenic ingredient in mushrooms, which he also enjoyed experimenting with.

Sandoz originally marketed the drug as Delysid and sold it in 100 microgram doses. From the late 1940s, through the early 1960s, the drug was legal and numerous psychologists and researchers began experimenting with it as a form of therapy. Many were willing participants in the CIA’s UKUltra mind control experiments, in which LSD was given to people, most of whom without their consent or knowledge. Cary Grant was a frequent and enthusiastic user. As early as the late 1940s, anthropologists Margaret Mead and Gregory Bateson became enthusiastic about its potential to unleash a new era of peace and expanded consciousness. The founder of Alcoholic Anonymous was also an early user and said that it was far more effective at treating alcoholism than any other treatment he knew of. Researcher John Lily, along with Gregory Bateson, began dosing dolphins in the early 1960s, in experiments connected with the U.S. military, in an attempt to learn to communicate with the animals and deploy them as weapons in the cold war. You can read more about Mead and Bateson’s role in promoting hallucinogens and in collaborating with the military and intelligence communities in Benjamin Breen’s book, Tripping on Utopia.

Exploring new dimensions of reality. What do you see? #PsychedelicArt"

When the mushrooms hit and you find your true self! #PsychedelicJourney"

If you're planning to celebrate Bicycle Day tomorrow --or even if you're not but you know what it is-- check this out:

https://etherdiver.bandcamp.com/track/any-day-can-be-bicycle-day-if-your-mind-is-in-the-right-gear

That's a track I wrote a couple years ago to celebrate this most holy of psychedelic holidays. Enjoy!

@electronicmusic
@psychedelicmusic

The Influence of Childhood Trauma on the Real-World Effectiveness of Ketamine in Adults With Treatment-Resistant Depression (Johnson, et al, 2025) https://onlinelibrary.wiley.com/doi/10.1111/acps.13812 #ketamine #ketaminetherapy #ketamineassistedtherapy #ketamineassistedpsychotherapy #mentalhealth #psychedelics #trauma #depression #psychedelic #psychedelicresearch

https://pubmed.ncbi.nlm.nih.gov/40247853/ Paramedic analgesia comparing ketamine and morphine in trauma (PACKMaN): a randomised, double-blind, phase 3 trial (Smyth, et al, 2025) #Ketamine non-inferior to morphine, no difference in rare serious adverse effects, no deaths in phase 3 study spanning 2 years #psychedelic #psychedelics #psychedelic #morphine #drugsafety

Adjunctive ketamine vs. buprenorphine in co-occurring major depressive disorder and opioid use disorder: a randomized, double-blind clinical trial assessing anxiety symptom severity and craving intensity (Mansoori, et al, 2025) #ketamine #addiction #recovery #opioids #depression #anxiety #ketaminetherapy #buprenorphine #psychedelic #psychedelics #psychedelicresearch #mentalhealth https://pubmed.ncbi.nlm.nih.gov/40247293/

Psilocybin and ketamine affect novel neuropeptides gene expression in the rat hypothalamus (Pałasz, et al, 2025) https://pubmed.ncbi.nlm.nih.gov/40243003/ #ketamine #psilocybin #psychedelics #psychedelic "results suggest for the first time that selected psychedelics may enhance the signaling of 5-HT2A receptors or inhibit NMDA receptor activity, affecting neuropeptide signaling and serotonin transmission in the rat hypothalamus, which may contribute to better understanding of psychedelic action in the brain

#Shrooms #Mushroom #Psilocybin #Psilocin #LSD #Psychedelics #HarmReduction

(comment on Spiss fleinsopp)

https://pubmed.ncbi.nlm.nih.gov/40237571/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Jks6COFDAP2wn10NWIf-H0HaQXEJkWUqtjQ12xwhgtqZed1QU&fc=20250204204106&ff=20250416143224&v=2.18.0.post9+e462414 Ketamine for unipolar depression: A systematic review of efficacy and safety (Peiris, et al, 2025) “Across 44 studies, ketamine significantly reduced depressive symptoms and suicidal ideation within hours, particularly in treatment-resistant cases” #ketamine #psychedelics #psychedelic #depression #mentalhealth #ketaminetherapy