Create accountLogin

Recent searches

No recent searches

Search options

Only available when logged in.
veganism.social is one of the many independent Mastodon servers you can use to participate in the fediverse.
Veganism Social is a welcoming space on the internet for vegans to connect and engage with the broader decentralized social media community.

Administered by:

Server stats:

294
active users

veganism.social: AboutStatusPrivacy policy

Mastodon: AboutGet the appKeyboard shortcutsView source codev4.3.0-alpha.5+vegan

#bioinformatics

9 posts8 participants2 posts today
Public
CSBJ

🧬Can we trust AI in bioinformatics if we don’t understand how it makes decisions?

As AI becomes central to bioinformatics, the opacity of its decision-making remains a major concern.

🔗 Demystifying the Black Box: A Survey on Explainable Artificial Intelligence (XAI) in Bioinformatics. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.csbj.2024.12

📚 CSBJ: csbj.org/

Demystifying the Black Box: A Survey on Explainable Artificial Intelligence (XAI) in Bioinformatics. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.12.027
ALT
#XAI#Bioinformatics#AIethics
Public
Luke Pembleton

Cloud computing: where you're not just a bioinformatician, you’re also the finance manager, compliance officer, and IT support, all while carrying a hefty dose of mental fatigue. I miss those PhD days with a inhouse HPC when all you had to do was sbatch every parameter combo under the sun to test your research question… then complain about queue times and who was clogging the damn cluster with their BLAST jobs 😅
#bioinformatics

Public
SIB Swiss Bioinformatics

@bgeedb was used to design stem-cell based vaccines 💉against #cancer in mouse models, opening a door to a potential application with humans.

🔎 This is an example of the impact that #bioinformatics databases and tools developed by SIB groups have. Researchers use them to make sense of their data and tackle essential societal challenges.

👉 Learn more: sib.swiss/services/open-softwa

@marcrr @fbastian

#SIBResourceImpacts#OpenSoftwareAndDatabases
Public
Benjamin Carr, Ph.D. 👨🏻‍💻🧬

#Genetic data repo #OpenSNP to self-destruct before authoritarians weaponize it
The reason, according to #bioinformatics researcher Bastian Greshake Tzovaras, one of the founders of the project, is the dissolution of genetic testing biz #23andMe and the potential weaponization of genetic data by #farright #authoritarian regimes.
theregister.com/2025/04/01/ope

The Register · Genetic data repo OpenSNP to self-destruct before authoritarians weaponize itBy Thomas Claburn
Public
Cytology and Genetics

A Pan-Cancer Analysis of Ferroptosis-Related Gene Arachidonic Acid 15-Lipoxygenase-1 (ALOX15): Its Prognostic and Immunotherapeutic Values - #ferroptosis #bioinformatics #prognosis #pancancer #ALOX15 #biologicalfunctions #immune - link.springer.com/article/10.3

SpringerLinkA Pan-Cancer Analysis of Ferroptosis-Related Gene Arachidonic Acid 15-Lipoxygenase-1 (ALOX15): Its Prognostic and Immunotherapeutic Values - Cytology and GeneticsAbstract Background. Emerging research has identified ferroptosis as a novel form of programmed cell death, and Arachidonic acid 15-lipoxygenase-1 (ALOX15) stands out as a pivotal gene in mediating this process. Nonetheless, the role of ALOX15 in human tumors remains elusive. Methods. We utilized TIMER 2.0 to investigate the differential expression profiles of ALOX15 between pan-cancer and normal tissues. Further data from the TCGA, GEPIA, UALCAN, HPA, and CPTAC databases were analyzed to verify the levels of mRNA, protein expression, and promoter methylation across various cancer types. The survival prognosis, clinical features, and genetic alterations of ALOX15 were also evaluated. GO/KEGG enrichment analyses and single-cell transcriptome sequencing were employed for functional enrichment analysis. The gene mutation of ALOX15 and its prognostic value were analyzed using the cBioPortal platform. Finally, the relationship between ALOX15 and immune cell infiltration, Immune Checkpoints (ICKs), genomic instability, and drug sensitivity was further explored using GSCA. Results. Our findings revealed that the transcription and protein expression of ALOX15 were significantly reduced in HNSC, LUAD, LUSC, SKCM, KICH, and THCA, while they were up-regulated in ESCA, LIHC, PRAD, and UCEC. Notably, the expression of ALOX15 had prognostic value for certain cancers, including LUAD, LUSC, LIHC, KIRC, HNSC, THCA, and LGG. Additionally, ALOX15 expression was markedly correlated with clinical characteristics, immune cell infiltration, ICKs, genomic instability, and antitumor drug sensitivity in various tumors. Gene mutations of ALOX15 and their prognostic value were discovered in pan-cancers. Furthermore, GO/KEGG analysis and single-cell transcriptome sequencing indicated that ALOX15 was significantly associated with cancer-related pathways. Conclusion. Our comprehensive pan-cancer analysis shed light on the role and significance of ALOX15, suggesting its potential as a prognostic and immunotherapeutic marker for pan-cancer. These findings may provide new directions and evidence for cancer therapeutics.
VegansExploreLive feeds
About